|
KMID : 0364820140500030223
|
|
Korean Journal of Microbiology
2014 Volume.50 No. 3 p.223 ~ p.226
|
|
|
Ethanol Extracts of Chungkookjang Stimulate the Proliferation and Migration of Human Umbilical Vascular Endothelial Cells
|
|
Hwang Jae-Sung
Sung Dae-Il
Lee Hwan-Myung
Chung Young-Shin
Kim Han-Bok
|
|
|
Abstract
|
|
|
In the fermented soybean product known as "chungkookjang", diverse bioactive compounds are produced when the
soybean proteins are degraded during fermentation. Vascular endothelial cells (EC) are crucial in vein function and
the formation of new vessels. A treatment to stimulate formation of new blood vessels is needed in cerebrovascular
diseases that lead to ischaemic stroke and heart attack, as well as for diabetic ulcers. VEGF (Vascular Endothelial
Growth Factor) simulates EC formation. The effect of Chungkookjang ethanol extract (CEE) on the proliferation of
EC was studied. CEE (100, 1000 μg/ml) and boiled CEE were as effective as VEGF (10 ng/ml) for the proliferation
of human umbilical vascular endothelial cells (HUVEC). The effect of CEE on the migration of HUVEC was
investigated using sprout analysis. CEE (100 μg/ml) was as effective as VEGF (10 ng/ml) for the migration of
HUVEC. Isolation of specific peptides influencing the growth and migration of EC is needed.
|
|
|
KEYWORD
|
|
|
Chungkookjang, HUVEC, peptide, sprout assay, VEGF
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|